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Pure Appl. Chem., 2010, Vol. 82, No. 4, pp. 991-999

http://dx.doi.org/10.1351/PAC-CON-09-10-02

Published online 2010-03-20

Effect of molecular clips and tweezers on enzymatic reactions by binding coenzymes and basic amino acids

Frank-Gerrit Klärner1*, Thomas Schrader1, Jolanta Polkowska1, Frank Bastkowski1, Peter Talbiersky1, Mireia Campañá Kuchenbrandt1, Torsten Schaller1, Herbert de Groot2 and Michael Kirsch2

1 Institute for Organic Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, 45117 Essen, Germany
2 Institute for Physiological Chemistry, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany

References

  • 1. Review: E. A. Meyer, R. K. Castellano, F. Diederich. Angew. Chem., Int. Ed. 42, 1210 (2003). (http://dx.doi.org/10.1002/anie.200390319)
  • 2. Reviews.
  • 2a. F.-G. Klärner, B. Kahlert. Acc. Chem. Res. 36, 919 (2003). (http://dx.doi.org/10.1021/ar0200448)
  • 2b. F.-G. Klärner, M. Campañá Kuchenbrandt. “Synthesis of molecular tweezers and clips by the use of a molecular Lego set and their supramolecular functions”, in Strategies and Tactics in Organic Synthesis, Vol. 7, Chap. 4, pp. 99–153, M. Harmata (Ed.), Academic Press-Elsevier, Amsterdam (2008).
  • 3a. M. Kamieth, F.-G. Klärner, F. Diederich. Angew. Chem., Int. Ed. 37, 3303 (1998). (http://dx.doi.org/10.1002/(SICI)1521-3773(19981217)37:23<3303::AID-ANIE3303>3.0.CO;2-T)
  • 3b. F.-G. Klärner, J. Panitzky, D. Preda, L. T. Scott. J. Mol. Model. 6, 318 (2000). (http://dx.doi.org/10.1007/PL00010733)
  • 3c. Most recently, the substituent effect on the electrostatic potential surface of aromatic systems was explained to be a through-space interaction largely S. E. Wheeler, K. N. Houk. J. Chem. Theory Comput. 5, 2301 (2009). (http://dx.doi.org/10.1021/ct900344g)
  • 4. M. Fokkens, T. Schrader, F.-G. Klärner. J. Am. Chem. Soc. 127, 14415 (2005). (http://dx.doi.org/10.1021/ja052806a)
  • 5. M. Fokkens, C. Jasper, T. Schrader, F. Koziol, C. Ochsenfeld, J. Polkowska, M. Lobert, B. Kahlert, F.-G. Klärner. Chem.–Eur. J. 11, 477 (2005). (http://dx.doi.org/10.1002/chem.200400603)
  • 6. T. Schrader, M. Fokkens, F.-G. Klärner, J. Polkowska, F. Bastkowski. J. Org. Chem. 70, 10227 (2005). (http://dx.doi.org/10.1021/jo0511896)
  • 7. F.-G. Klärner, B. Kahlert, A. Nellesen, J. Zienau, C. Ochsenfeld, T. Schrader. J. Am. Chem. Soc. 128, 4831 (2006). (http://dx.doi.org/10.1021/ja058410g)
  • 8. B. Branchi, P. Ceroni, V. Balzani, M. C. Cartagena, F.-G. Klärner, T. Schrader, F. Vögtle. New J. Chem. 33, 397 (2009). (http://dx.doi.org/10.1039/b812672k)
  • 9. B. Branchi, V. Balzani, P. Ceroni, M. Campañá Kuchenbrandt, F.-G. Klärner, D. Bläser, R. Boese. J. Org. Chem. 73, 5839 (2008). (http://dx.doi.org/10.1021/jo8007513)
  • 10. The preparation of molecular clip 6b and the determination of the thermodynamic parameters listed in Table 1 for the formation of its self-assembled dimer (6b)2 are described by M. Campañá Kuchenbrandt, Ph.D. thesis, University of Duisburg-Essen, 2007, and in the Supplementary Information.
  • 11. C. J. Breitkreuz. Diploma thesis, University of Duisburg-Essen (2006).
  • 12. J. Polkowska, F. Bastkowski, T. Schrader, F.-G. Klärner, J. Zienau, F. Koziol, C. Ochsenfeld. J. Phys. Org. Chem. 22, 779 (2009). (http://dx.doi.org/10.1002/poc.1519)
  • 13. P. Talbiersky, F. Bastkowski, F.-G. Klärner, T. Schrader. J. Am. Chem. Soc. 130, 9824 (2008). (http://dx.doi.org/10.1021/ja801441j)
  • 14. M. Kirsch, P. Talbiersky, J. Polkowska, F. Bastkowski, T. Schaller, H. de Groot, F.-G. Klärner, T. Schrader. Angew. Chem., Int. Ed. 48, 2886 (2009). (http://dx.doi.org/10.1002/anie.200806175)
  • 15a. M. Dixon, E. C. Webb. Enzymes, pp. 343–344, Longman, London (1979).
  • 15b. C. G. Whiteley. Biochem. Educ. 28, 144 (2000). (http://dx.doi.org/10.1016/S0307-4412(00)00029-7)